Yazar "Demirayak, Şeref" için listeleme
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Antimicrobial activity evaluation of new 1,3,4-oxadiazole derivatives
Yurttaş, Leyla; Bülbül, Emre Fatih; Tekinkoca, Sinem; Demirayak, Şeref (University of Istanbul, 2017)In this study, we have synthesized seven novel 2-[(5-(4-chlorobenzyl)-1,3,4-oxadiazol-2-yl)thio]-N-(6-substituted benzothiazol-2-yl)acetamide derivatives (4ag) starting from ethyl 4-chlorophenyl acetate. The antimicrobial ... -
Antimicrobial evaluation of trisubstituted 2-piperazinyl thiazoles
Giray, Betül; Yurttaş, Leyla; Şahin, Zafer; Berk, Barkın; Demirayak, Şeref (İstanbul Medipol University, 2019)Thiazole and basic nitrogen containing rings are important chemical moieties of antimicrobial drugs. In recent, third generation cephalosporins include thiazole ring system. In this study, we synthesized 33 piperazine ... -
Ayak problemlerinde tabanlık kullanımında eczacının rolü
Kara, Gül (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2018)Vücut ağırlığının yaklaşık %25 sini taşımakla görevli bir organ olan ayak, topuk, orta ve ön ayak kısımlarından oluşur. Vücutta tamponlayıcı ve baskıyı süspande edici bir organdır. Taşıdığı yükü düzgün şekilde dağıtan bu ... -
Cytotoxic, antiproliferative and apoptotic effects of new benzimidazole derivatives on A549 lung carcinoma and C6 glioma cell lines
Yurttaş, Leyla; Demirayak, Şeref; Çiftçi, Gülşen Akalın (Bentham Science Publishers, 2015)Benzimidazole ring is a versatile structure which has been extensively utilized in medicinal chemistry. Since we are working on 1,2-disubstutited benzimidazoles, we have reported new antitumor active derivatives. As a ... -
Design and synthesis of new donepezil analogs derived from arylpiperazine scaffold as acetylcholinesterase inhibitors
Şahin, Zafer; Biltekin, Sevde Nur; Bülbül, Emre Fatih; Yurttaş, Leyla; Berk, Barkın; Demirayak, Şeref (Taylor & Francis Ltd, 2020)Newly synthesized 4-substituted phenyl-2-(4-substituted phenylpiperazine-1-yl)thiazole derivatives (4a-v) were evaluated in terms of their acetylcholinesterase (AChE) inhibition activities. Twenty-two compounds were tested ... -
Determination and evaluation of acidity constants of some imidazole and thiazole linked acetamide compounds
Tay, Naime Funda; Duran, Murat; İspir, Cihan; Demirayak, Şeref (Anadolu University, 2016)In this work, the effect of substituents on the acidity constants of some acetamide derivatives was investigated. The acidity constants of nine acetamide derivatives were determined at 25 °C using a UV spectrophotometric ... -
Discovery of novel potent human chondrosarcoma (SW1353) inhibitors: 4-(2/3/4-pyridyl)thiazole 2-acetamide derivatives
Coşkun, Göknil Pelin; Şahin, Zafer; Erdoğan, Ömer; Çevik, Özge; Biltekin, Sevde Nur; Yurttaş, Leyla; Berk, Barkın; Ülgen, Mert; Demirayak, Şeref (Elsevier B.V., 2023)Chondrosarcoma is the most common cartilage sarcoma among adult patients. It is mainly observed after the degradation of chondrocytes in the case of cell stress. Unfortunately, the mortality among patients is high as a ... -
Diyabet tedavisine hasta uyumunda insülin iğneleri ve iğne uçları
Aykanat, Kazım (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2018)Diyabetli bir hastanın ülkemizde senelik yaklaşık 1000 dolar masrafı bulunmaktadır.Ülkemizde şeker hastalığı (Diabetes Mellitus) için yapılan toplam harcama ise senede 1-2 milyar dolar civarındadır. Hasta herhangi bir ... -
The effects of some imidazopyrazine derivatives on telomerase inhibition, mtDNA damage and mtDNA copy number
Mutlu, Ayşe Gül; Bilginer, Abdulkerim; Kayağil, İsmail; Yıldız, Hülya; Bayhan, Ülkü; Yılmaz, İnanç; Demirayak, Şeref (University of Istanbul, 2017)Imidazopyrazine derivatives have been studied for their curative effects on some diseases like cancer and neurological problems; also, some of these molecules have been patented. Primary human cells exhibit limited replicative ... -
Geriatrik hasta reçetelerindeki ilaç etkileşimleri ve doz aşımlarının incelenmesi
Köroğlu, Ayşe Lerzan (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2018)İnsanlar yaş aldıkça gerek beyinde gerek vücutta gerçekleşmesi gereken reaksiyonlar, iletimler, ilgili dokuların hasarlarından kaynaklı aksaklıklara uğramaktadır. İlaçların farmakokinetiğini ve hastalıkların gelişimini ... -
In vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells
Yurttaş, Leyla; Demirayak, Şeref; Ilgın, Sinem; Atlı, Özlem (Elsevier Ltd, 2014)A series of 1,2,4-triazine derivatives bearing piperazine amide moiety has been synthesized and investigated for their potential anticancer activities. 1-[4-(5,6-Bis (4-subtituted phenyl) -1,2,4-triazin-3-yl)piperazin-1- ... -
Metoprolol kullanan hastalarda eş zamanlı NSAİİ kullanımı ve ilaç etkileşimi
Karabağ, Esin (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2019)Steroid olmayan anti-inflamatuar ilaçlar (NSAİİ'ler), romatoid artrit, osteoartrit ve gut gibi hastalıklarda hastaların tedavisinin yanında, hastaların ağrılarını hafifletmek için de sıklıkla kullanılmaktadır. Çok sayıda ... -
Microwave supported synthesis of some novel 1,3-Diarylpyrazino[1,2-a] benzimidazole derivatives and investigation of their anticancer activities
Demirayak, Şeref; Kayagil, İsmail; Yurttaş, Leyla (Elsevier, 2011)The syntheses of 1,3-diarylpyrazino[1,2-a]benzimidazole derivatives and the investigation of their anticancer activities were studied. For this, 2-aryloylbenzimidazole derivatives were reacted with 2-bromoacetophenones in ... -
Montelukast sodyum içeren preparatlarda hasta uyuncunun ölçülmesi
Karabağ, İlker Ozan (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2019)Bu çalışmada, montelukast sodyum içeren preparatları kullanan astım hastalarında uyuncun ölçülmesi amaçlanmıştır. Dünya sağlık örgütü (WHO), dünyadaki hastaların %1'inde astım hastalığı olduğunu ve her yıl 15 milyon astım ... -
New chroman-4-one/thiochroman-4-one derivatives as potential anticancer agents
Demirayak, Şeref; Yurttaş, Leyla; Gündoğdu-Karaburun, Nalan; Karaburun, Ahmet Çagrı; Kayagil, İsmail (Elsevier Science Bv, 2017)The synthesis of 3-[3/4-(2-aryl-2-oxoethoxy) arylidene] chroman/thiochroman-4-one derivatives (1-34) and evaluation of their anticancer activities were aimed in this work. Final compounds were obtained in multistep synthesis ... -
Novel benzimidazole derivatives: Cytotoxic and apoptotic properties on lung cancer cell line
Yurttaş, Leyla; Akalın Çiftçi, Gülşen; Aksoy, Mehmet Onur; Demirayak, Şeref (Bentham Science Publishers, 2020)Background: Benzimidazole derivatives are privileged molecules known to have a wide variety of biological activities. In medicinal chemistry, due to the ring's structural similarity to nucleotides, its derivatives were ... -
Novel benzofurane carbonyl analogs of donepezil as acetylcholinesterase inhibitors
Şahin, Zafer; Biltekin, Sevde Nur; Yurttaş, Leyla; Berk, Barkın; Küçükkılınç, Tuba Tüylü; Demirayak, Şeref (Elsevier B.V., 2022)Donepezil is the most prescribed drug for mild to moderate Alzheimer's Disease. There is not any alternative drug with this potency yet. New scaffolds bearing benzofurans and amines are being tested for good potency on ... -
Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation
Şahin, Zafer; Özhan, Yağmur; Sipahi, Hande; Biltekin, Sevde Nur; Yurttaş, Leyla; Berk, Barkın; Demirayak, Şeref (Walter de Gruyter GmbH, 2022)Novel benzofurane-pyrazolone hybrids have been synthesized for evaluating their anti-inflammatory and cytotoxic properties. 4-(2-chloroacetyl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one were reacted with alpha-hydroxy ... -
Novel benzothiazole based imidazole derivatives as new cytotoxic agents against glioma (C6) and liver (HepG2) cancer cell lines
Yurttaş, Leyla; Ertaş, Merve; Akalın Çiftçi, Gülşen; Temel, Halide Edip; Demirayak, Şeref (University of Istanbul, 2017)In this work, some novel N-(6-substituted-benzothiazol-2-yl)-2-[[4,5-dimethyl-1-((p-tolyl/4-nitrophenyl)amino)-1H-imidazol-2-yl]thio]acetamide derivatives were synthesized and searched for their cytotoxic activities against ... -
Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition
Şahin, Zafer; Biltekin, Sevde Nur; Yurttaş, Leyla; Berk, Barkın; Özhan, Yağmur; Sipahi, Hande; Gao, Zhanguo; Jacobson, Kenneth A.; Demirayak, Şeref (Elsevier France-Editions Scientifiques Medicales Elsevier, 2021)Thiouracil and thiocytosine are important heterocyclic pharmacophores having pharmacological diversity. Antitumor and antiviral activity is commonly associated with thiouracil and thiocytosine derivatives, which are well ...